[An antifolate derived from diaminopyrimidine with cytotoxic properties. With a mechanism of action similar to that of methotrexate (MTX), m-azidopyrimethamine blocks tetrahydrofolate synthesis, resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. This agent is more lipophilic but less potent than MTX. (NCI04) ( NCI )]
UMLS (NCI) C0280485 - Amino Acid, Peptide, or Protein
- Pharmacologic Substance