MAP3K1

1. [This gene plays a role in mediating cellular responses to growth factors, metabolic stimuli and mitogens. ( NCI )]
   UMLS (NCI) C1367675
   
   MAP3K1 Gene
   Mitogen-Activated Protein Kinase Kinase Kinase 1 Gene
    

   Gene or Genome

2. [Encoded by MAP3K1 Gene (MAP3K Family), MEKK1 Protein is pivotal in the Ser/Thr phosphorylation network that integrates cellular responses to mitogenic and metabolic stimuli. IFNG induces MEKK1 expression. An efficient activator of the JNK cascade, MEKK1 can phosphorylate MEK1/MEK2, which activate MAPKs. The PHD domain of MEKK1, a RING-type zinc finger, exhibits E3 ubiquitin ligase activity toward ERK2. Thus, MEKK1 functions as both an upstream activator of ERK and JNK through its kinase domain and as an E3 ligase through its PHD domain, decreasing ERK1/ERK2 activity. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
   UMLS (NCI) C1367798
   
   MAPK/ERK Kinase Kinase 1
   MEK Kinase
   MEK Kinase 1
   MEKK1 Protein
   Mitogen-Activated Kinase Kinase Kinase 1
   Mitogen-Activated Protein Kinase Kinase Kinase 1
    

   Amino Acid, Peptide, or Protein

   Enzyme