MO MOA MOB MOC MOD MOE MOF MOG MOH MOI MOK MOL MOM MON MOO MOP MOQ MOR MOS MOT MOU MOV MOW MOX MOY MOZ
MONO dgA RFB4
[An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to a single deglycosylated ricin toxin A-chain (dgA), originated from castor bean. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This agent limits specific cytotoxicity of ricin toxin to CD22-positive malignant cells. ( NCI )]
UMLS (NCI) C0935906Monoclonal Antibody Mono-dgA-RFB4
- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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