UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
M M0 M1 M2 M4 M5 M7 M8 M9 MA MB MC MD ME MF MG MH MI MK ML MM MN MO MP MR MS MT MU MV MY
MPA MPD MPE MPH MPL MPP MPT MPZ

MPZL1

  1. [This gene plays a role in cell migration. ( NCI )]
    UMLS (NCI) C1334528
    MPZL1 Gene
    Myelin Protein Zero-Like 1 Gene
     
    Gene or Genome
  2. [Widely expressed (highest in heart, placenta, kidney, and pancreas) by human MPZL1 Gene (Ig Superfamily), 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein Myelin Protein Zero-Like 1 Protein contains an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with Myelin Protein Zero, MPZL1 may have a role in cell signaling via c-Src. (NCI) ( NCI )]
    UMLS (NCI) C1334837
    Myelin Protein Zero-Like 1
    Protein Zero-Related
    PZR
     
    Amino Acid, Peptide, or Protein
    Biologically Active Substance

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