MPZL1

1. [This gene plays a role in cell migration. ( NCI )]
   UMLS (NCI) C1334528
   
   MPZL1 Gene
   Myelin Protein Zero-Like 1 Gene
    

   Gene or Genome
   

2. [Widely expressed (highest in heart, placenta, kidney, and pancreas) by human MPZL1 Gene (Ig Superfamily), 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein Myelin Protein Zero-Like 1 Protein contains an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with Myelin Protein Zero, MPZL1 may have a role in cell signaling via c-Src. (NCI) ( NCI )]
   UMLS (NCI) C1334837
   
   Myelin Protein Zero-Like 1
   Protein Zero-Related
   PZR
   
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance