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Monoclonal Antibody GD2 Anti-Idiotype Vaccine
[A class of vaccines that consist of anti-idiotype monoclonal antibodies against the tumor-associated antigen disialoganglioside GD2 with potential antineoplastic activity. Vaccination with a monoclonal antibody GD2 anti-idiotype vaccine produces an immunoglobulin response against GD2 with subsequent destruction of GD2 positive tumor cells via antibody-dependent cellular cytotoxicity (ADCC). GD2 is overexpressed in melanoma, neuroblastoma, soft tissue sarcoma, and small cell carcinoma of the lung. (NCI04) ( NCI )]
UMLS (NCI) C1328690- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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