Mycophenolate
[The morpholinoethyl ester of mycophenolic acid (MPA). As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation. MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04) ( NCI )]
UMLS (NCI) C0883242MYCOPHENOLATE PREPARATION
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [IM600] IMMUNE SUPPRESSANTS
RS 61443
RS 61443
Relation/CHD: MMF
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