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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
N N- N0 N3 NA NB NC ND NE NF NG NH NI NK NL NM NN NO NP NR NS NT NU NV NX NY NZ
NE NE- NEA NEB NEC NED NEE NEF NEG NEI NEL NEM NEN NEO NEP NER NES NET NEU NEV NEW NEX NEZ

Nerve Growth Factor Receptor Type 1

[Human NTRK1 Gene (TKRI/INSR Family) encodes neuronal TRKA-I and non-neural TRKA-II isoforms (similar biological properties) of type I membrane protein Neurotrophic Tyrosine Kinase Receptor Type 1, containing 2 LRR repeats and 2 Ig-like C2-type domains. NTRK1 exists in dynamic equilibrium as low affinity monomers and high affinity dimers with TRKA, TRKB, or TRKC to bind NGF, NTF3, NTF4/5, and BDNF neurotrophins that regulate development and function of the nociceptive and thermoregulatory nervous systems. Ligand stimulation of TRK activates autophosphorylation, SHC, PI-3 kinase, PLC-gamma-1, and ERK1 signaling pathways. NTRK1 defects cause CIPA. Chromosomal rearrangements of NTRK1 fused to TPM3 or to TFG in t(1;3)(q21;q11) are associated with papillary thyroid carcinoma. (NCI) ( NCI )]
UMLS (NCI) C0072482
 
Amino Acid, Peptide, or Protein
Enzyme
Receptor

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