Neurite Growth Inhibitor 220
[Nogo are high molecular weight transmembrane inhibitors of neurite out-growth found in CNS myelin. Nogo is expressed by oligodendrocytes in white matter of the CNS, but not by Schwann cells in peripheral nerves. The C-terminal region shares homology with neuroendocrine-specific proteins and other members of the reticulon gene family. NOGO consists of a putative large extracellular domain with seven predicted N-linked glycosylation sites, two or three transmembrane domains, and a short C-terminal region. An extracellular domain of NOGO inhibits axonal extension but does not alter non-neuronal cell morphology. Nogo A, B, and C are encoded as splice variants of a single gene. (from OMIM 604475 and NCI) ( NCI )]
UMLS (NCI) C1309732Neurite Outgrowth Inhibitor
Neuroendocrine-Specific Protein C Like (foocen)
Nogo-A
Reticulon 4
Neuroendocrine-Specific Protein C Like (foocen)
Nogo-A
Reticulon 4
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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