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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
N N- N0 N3 NA NB NC ND NE NF NG NH NI NK NL NM NN NO NP NR NS NT NU NV NX NY NZ
NE NE- NEA NEB NEC NED NEE NEF NEG NEI NEL NEM NEN NEO NEP NER NES NET NEU NEV NEW NEX NEZ

Neuronal SHC

[Expressed in the brain by human SHC3 Gene, the 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC are similar to SHC; nearly 70% homology in the PTB and SH2 domains. SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB. (NCI) ( NCI )]
UMLS (NCI) C1312067
Neuronal SHC-Like Protein
NSHC
SHC3
SHCC
SRC Homology 2 Domain Containing Transforming Protein C3
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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