P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
PP2A-Beta
[Encoded by human PPP2CB Gene (PP1 Family), ubiquitous 309-aa 36-kDa cytoplasmic serine/threonine-specific Protein Phosphatase 2 Catalytic Subunit Beta forms a core complex with a PR65/A subunit; association with additional regulatory subunits that control substrate selectivity/activity forms as a specific PP2A trimeric holoenzyme. PPP2CB is regulated by inactivating threonine or tyrosine phosphorylation and reversible carboxy methylation. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. In dephosphorylating protein kinases and transcription factors, PPP2CB regulates major metabolic pathways, translation, transcription, and G2/M transition. (NCI) ( NCI )]
UMLS (NCI) C1335540PPP2CB
Protein Phosphatase 2 Catalytic Subunit Beta
Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta
Protein Phosphatase 2 Catalytic Subunit Beta
Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta
- Amino Acid, Peptide, or Protein
- Enzyme
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