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PPI-2458
[A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties. PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. (NCI04) ( NCI )]
UMLS (NCI) C1505437- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
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