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STAF28
[Encoded by human TAF10 Gene (TAF2H Family), 218-aa nuclear Transcription Initiation Factor TFIID 30 kDa Subunit is a small subunit of TFIID and associated with a subset of TFIID complexes. A component of the PCAF complex, the TFTC-HAT complex, and the STAGA transcription coactivator-HAT complex, TAF10 is required for transcriptional activation by estrogen receptor, for cell cycle progression, and may be required for some cell differentiation programs. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. ( NCI )]
UMLS (NCI) C0289408- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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