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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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S S S- S0 S1 S2 S3 S4 S5 S6 S7 S8 S9 SA SB SC SD SE SF SG SH SI SJ SK SL SM SN SO SP SQ SR SS ST SU SV SW SY
SE SEA SEB SEC SED SEE SEG SEI SEL SEM SEN SEO SEP SEQ SER SES SET SEV SEW SEX SEZ

Semaxanib

[A derivative of quinolone Semaxanib blocks ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), thereby inhibiting VEGF-stimulated endothelial cell migration and proliferation and decreasing the density of microvessels supplying tumors. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. Semaxanib has been studied for potential antineoplastic properties. (NCI04) ( NCI )]
UMLS (NCI) C1135174
 
Organic Chemical
Pharmacologic Substance

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