beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate
[A sulfamate-substituted monosaccharide with anticonvulsant property. Although the mechanism of action has not been fully elucidated, topiramate antagonizes kainate/AMPA subtype of the glutamate receptors, which are ligand-activated cation channels that mediate the fast component of excitatory postsynaptic currents in neurons of the central nervous system. This antagonistic action results in stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing propagation of synaptic impulses, thereby impedes seizure occurrences. In addition, this agent augments gamma-aminobenzoic acid (GABA) activity and thereby attenuating GABAnergic inhibitory transmission. ( NCI )]
UMLS (NCI) C0076829- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CN400] ANTICONVULSANTS
fructose
fructose
Relation/CHD: TOPIRAMATE 15 MG
TOPIRAMATE 200 MG
TOPIRAMATE 25 MG
TOPIRAMATE 100 MG
TOPIRAMATE 200 MG
TOPIRAMATE 25 MG
TOPIRAMATE 100 MG
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