- 1. (3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl) Methanone
- [A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen. ( NCI )] (UMLS (NCI) C0077238) =Organic Chemical; Pharmacologic Substance ;
| - 27. 3,4 dihydroxyphenylacetate
- [metabolite of DOPA. ( CSP )] (UMLS (CSP) C0178432) =Organic Chemical ;
=phenylacetate;
|
- 2. 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amine
- [A tricyclic nucleoside with potential antineoplastic activity. As a purine analog, triciribine phosphate inhibits the enzymes amidophosphoribosyltransferase and inosine monophosphate dehydrogenase, resulting in decreased purine nucleotide biosynthesis, decreased DNA and protein synthesis, and cell cycle arrest. This agent may also exhibit antiviral activity. (NCI04) ( NCI )] (UMLS (NCI) C0077070) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 28. 3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione
- [A naphthoquinone compound derived from bark of Tabebuia sp., with antitumor, antibacterial, antifungal and antitrypanosomal activities. Beta-lapachone exerts its anti-tumor effect by indirect actions of inducing p53-independent apoptosis and cell cycle arrest mediated through altered activities of cell cycle control regulatory proteins; including down-regulating retinoblastoma protein (pRB), a transcriptional repressor target at transcription factor E2F-1, as well as induces expression of cyclin dependent kinase inhibitor 1A (CDKN1A or p21). Both E2F-1 and p21 are required for G1/S-phase transition during cell cycle. This agent also inhibits DNA topoisomerase I by a mechanism distinct from that of camptothecin, and thereby blocks the formation of a cleavable complex leading to enzyme inhibition and prevent DNA repair. Furthermore, beta-lapachone could induce reactive oxygen species in vivo, and result in cytotoxicity. ( NCI )] (UMLS (NCI) C0053471) =Organic Chemical; Pharmacologic Substance ;
|
- 3. 1,2 dihydroxybenzene
- [A chemical originally isolated from a type of mimosa tree. Catechol is used as an astringent, an antiseptic, and in photography, electroplating, and making other chemicals. It can also be man-made. ( NCI )] (UMLS (NCI) C0054858) =Organic Chemical; Pharmacologic Substance
| - 29. 3,4-Dihydro-2-amino-6-methyl-4-oxy-5-(4-pyridylthio)-quinazoline Dihydrochloride
- [The hydrochloride salt form of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity. (NCI04) ( NCI )] (UMLS (NCI) C0389037) =Organic Chemical; Pharmacologic Substance
|
- 4. 1,2-Dihydro-3-methyl-benz(j)aceanthrylene
- [A polycyclic aromatic hydrocarbon that consists of five fused rings with carcinogenic activity. 20-Methylcholanthrene is often used in experimental cancer studies. ( NCI )] (UMLS (NCI) C0000325) =Organic Chemical; Hazardous or Poisonous Substance ;
| - 30. 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide
- [dacarbazine derivative; alkylating antineoplastic agent. ( CSP )] (UMLS (NCI) C0076080) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-;
Antineoplastic Alkylating Agent;
=TEMOZOLOMIDE 20 MG;
TEMOZOLOMIDE 100 MG;
TEMOZOLOMIDE 5 MG;
TEMOZOLOMIDE 250 MG;
|
- 5. 1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilide
- [A quinoline-3-carboxamide with potential antineoplastic activity. Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis. This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04) ( NCI )] (UMLS (NCI) C0244748) =Organic Chemical; Pharmacologic Substance ;
| - 31. 3,4-dihydroxy-4'-methyl-5-nitrobenzophenone
- [A benzophenone derivative and a catechol-O-methyltransferase (COMT) inhibitor. Tolcapone selectively and reversibly inhibits COMT, an enzyme that catalyzes the metabolism of biologically active catechols and their hydroxylated metabolites by transferring the methyl group of S-adenosyl-L-methionine to the phenolic group of catechol-containing substrates. When given in conjunction with a peripheral dopa decarboxylase inhibitor and levodopa, tolcapone may prevent the metabolism of levodopa to 3-methoxy-4-hydroxy- L-phenylalanine (3-OMD) in the brain and peripheral tissues leading to increased bioavailability and enhancement of delivery to the central nervous system (CNS) of levodopa. ( NCI )] (UMLS (NCI) C0246330) =Organic Chemical; Pharmacologic Substance ;
=[CN500] ANTIPARKINSON AGENTS;
Benzophenones =TOLCAPONE 100 MG;
TOLCAPONE 200 MG;
|
- 6. 1,2-Dihydroxypropane
- [A clear, colorless, viscous organic solvent and diluent used in pharmaceutical preparations. ( MSH )] (UMLS (NCI) C0072225) =Organic Chemical; Biomedical or Dental Material =propanediol;
PROPYLENE =PROPYLENE GLYCOL STEARATE;
PROPYLENE GLYCOL DIACETATE;
CONTACT LENS CLEANING SOLN;
COAL TAR DISTILLATE;
MASSENGILL DISPOSABLE DOUCHE;
TING PWDR,TOP;
fluticasone 0.5 MG/ML Topical Cream;
KERI LOTION;
fluticasone 0.00005 MG/MG Topical Ointment;
CAFFEINE 200 MG Oral (systemic) tablet;
Urea 0.1 MG/MG Topical Ointment;
UREA 25% LOTION;
CETAPHIL CREAM;
CETAPHIL LOTION; More… | - 32. 3,4-Dihydroxybenzohydroxamic acid
- [3,4-dihydroxybenzohydroxamic acid. An inhibitor of ribonucleotide reductase. ( NCI )] (UMLS (NCI) C0094556) =Organic Chemical; Pharmacologic Substance ;
|
- 7. 1,25-Dihydroxy-16-ene-23-yne-Vitamin D3
- (UMLS (NCI) C0526577) =Steroid; Pharmacologic Substance
| - 33. 3,4-Dihydroxyphenylethanol
- (UMLS (NCI) C0046981) =Organic Chemical; Pharmacologic Substance
|
- 8. 1,25-Dihydroxyvitamin D3 Receptor
- [use for receptors of any of the D vitamins. ( CSP )] (UMLS (NCI) C0108082) =Amino Acid, Peptide, or Protein; Receptor =vitamin receptor;
| - 34. 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione
- [1,3-dimethylxanthine; methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. ( CSP )] (UMLS (NCI) C0039771) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance =bronchodilator;
Xanthine Alkaloids;
xanthine;
Muscle Relaxant;
methylpurine;
[RE104] BRONCHODILATORS, XANTHINE-DERIVATIVE =1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1);
DIMENHYDRINATE;
1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl;
Choline, hydroxide, compound with Theophylline(1:1);
pamabrom;
Theophylline Anhydrous;
THEOPHYLLINE CALCIUM SALICYLATE;
THEOPHYLLINE SODIUM GLYCINATE;
THEOPHYLLINE CALCIUM SALICYLATE;
THEOPHYLLINE SODIUM GLYCINATE;
THEOPHYLLINE 0.4 MG/ML;
THEOPHYLLINE 0.8 MG/ML;
Theophylline 10 MG/ML;
THEOPHYLLINE 100 MG;
THEOPHYLLINE 120 MG;
THEOPHYLLINE 125 MG;
THEOPHYLLINE 2 MG/ML;
THEOPHYLLINE 250 MG;
THEOPHYLLINE 3.2 MG/ML;
THEOPHYLLINE 300 MG;
THEOPHYLLINE 4 MG/ML;
THEOPHYLLINE 450 MG;
THEOPHYLLINE 600 MG;
THEOPHYLLINE 1.6 MG/ML;
THEOPHYLLINE 200 MG;
THEOPHYLLINE 400 MG;
THEOPHYLLINE 100 MG/18.75ML;
THEOPHYLLINE 100 MG/15ML;
Theophylline 10.7 MG/ML;
Theophylline 5.9 MG/ML;
THEOPHYLLINE SODIUMGLYCINATE;
THEOPHYLLINE 80 MG/15ML;
|
- 9. 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione
- [1,4-dihydroxy-5,8-bis((2-((2-hydroxyethyl) -amino) ethyl)amino) anthraquinone; cytotoxic compound with potentially therapeutic antitumor activity in breast cancer, lymphoma, and leukemia. ( CSP )] (UMLS (NCI) C0026259) =Organic Chemical; Pharmacologic Substance ;
=anthracene;
Anthracenedione;
[AN000] ANTINEOPLASTICS;
=1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride | - 35. 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione
- [metabolite of pentifylline (a preparation of theobromine and hexyl halide); used as a vasodilator. ( CSP )] (UMLS (NCI) C0030899) =Organic Chemical; Pharmacologic Substance ;
=theobromine;
Vasodilating Agent;
[CV900] CARDIOVASCULAR AGENTS, OTHER;
=PENTOXIFYLLINE 400 MG;
|
- 10. 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride
- [The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication. This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair. Mitoxantrone is less cardiotoxic compared to doxorubicin. ( NCI )] (UMLS (NCI) C0700458) =Organic Chemical; Pharmacologic Substance =Mitoxantrone;
=MITOXANTRONE HYDROCHLORIDE 2 MG/ML | - 36. 3-(2,5-Dihydroxyphenyl)-2-propenoic Acid Methyl Ester
- [A cell-permeable analog of erbstatin, a compound isolated from Streptomyces that inhibits the autophosphorylation of epidermal growth factor receptor. Erbstatin analogue competitively inhibits epidermal growth factor receptor-associated tyrosine kinase, inhibiting the activation of v-abl tyrosine kinase. In addition, this agent has induced apoptosis in mouse thymocytes and inhibits the G2/M phase of the cell cycle. (NCI) ( NCI )] (UMLS (NCI) C0083406) =Organic Chemical; Pharmacologic Substance
|
- 11. 1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid
- [A synthetic, broad-spectrum fluoroquinolone with antibacterial activity. Norfloxacin inhibits activity of DNA gyrase, thereby blocking bacterial DNA replication. Norfloxacin concentrates in the renal tubules and bladder and is bactericidal against a wide range of aerobic gram-positive and gram-negative organisms. ( NCI )] (UMLS (NCI) C0028365) =Organic Chemical; Pharmacologic Substance ;
=Quinolones;
[AM900] ANTI-INFECTIVES, OTHER =NORFLOXACIN 400 MG;
NORFLOXACIN 0.3 % | - 37. 4',7-Dihydroxyisoflavone
- [An isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties. (NCI) ( NCI )] (UMLS (NCI) C0057090) =Organic Chemical; Vitamin ;
|
- 12. 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one
- [drug used to treat gout and other conditions in which there is an excessive buildup of uric acid. ( CSP )] (UMLS (NCI) C0002144) =Organic Chemical; Pharmacologic Substance ;
| - 38. 5-(((2,5-Dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxy Benzoic Acid
- [A compound isolated from strains of Streptomyces griseolavendus that may exert antitumor activity by inhibition of protein tyrosine kinase and tubulin polymerization. (NCI) ( NCI )] (UMLS (NCI) C0064695) =Organic Chemical; Pharmacologic Substance ;
|
- 13. 1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one Monosodium Salt
- [The sodium form of allopurinol, which is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04) ( NCI )] (UMLS (NCI) C0278766) =Organic Chemical; Pharmacologic Substance
| - 39. 5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl\-2,4-thiazolidinedione
- [A drug used in diabetes treatment that is being studied for its effect on reducing the risk of cancer cell growth in fat tissue. ( NCI )] (UMLS (NCI) C0245514) =Organic Chemical; Pharmacologic Substance ;
=Chromans;
antihyperglycemic;
thiazole;
Unclassified Ingredient Preparations |
- 14. 1,7-Dihydro-6H-purine-6-thione
- [An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0000618) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 40. 6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester
- [A synthetic, topical retinoid. Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene. In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04) ( NCI )] (UMLS (NCI) C0288792) =Organic Chemical; Pharmacologic Substance ;
=Nicotinic Acids;
[DE752] ANTIACNE AGENTS, TOPICAL =TAZAROTENE 0.1 %;
TAZAROTENE 0.05 % |
- 15. 1,8-Dihydroxy-9(10H)-anthracenone
- [A natural anthraquinone derivative, anti-psoriatic and anti-inflammatory Anthralin (dithranol) controls skin growth by reducing DNA synthesis and mitotic activity in the hyperplastic epidermis, restoring a normal rate of cell proliferation and keratinization. Used topically in the treatment of psoriasis, dermatoses, and alopecia areata, it is also used in biomedical research due to its effect on EGFR autophosphorylation. (NCI04) ( NCI )] (UMLS (NCI) C0003166) =Organic Chemical; Pharmacologic Substance
| - 41. 7,8-Dihydro-8-Oxoguanine Triphosphatase
- [Human 7,8-dihydro-8-oxoguanine triphosphatase protein (197 aa, 23 kD - unprocessed precursor) is encoded by the nudix (nucleoside diphosphate linked moiety X)-type motif 1 gene (NUDT1). Isoforms of this soluble protein are localized to both the cytoplasm and mitochondria of the cell. It catalyzes the hydrolysis of 8-oxo-dGTP to yield 8-oxo-dGMP and diphosphate. Misincorporation of 8-oxo-dGTP into DNA can result in A:T to C:G transversion mutations. Therefore, this enzyme is considered to be antimutagenic. ( NCI )] (UMLS (NCI) C0210507) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 16. 1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one Monosodium Salt
- [The sodium salt form of penciclovir, a synthetic acyclic guanine derivative with antiviral activity, mainly used to treat infections from herpes simplex virus (HSV) types 1 and 2. In HSV infected cells, penciclovir is phosphorylated by viral thymidine kinase and subsequently converted by cellular kinases into the active metabolite, penciclovir triphosphate, which competitively inhibits viral HSV polymerase by blocking deoxyguanosine triphosphate substrate binding. As a result, herpes viral DNA synthesis and replication are selectively inhibited. ( NCI )] (UMLS (NCI) C0892839) 9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Monosodium Salt;
PENCICLOVIR SODIUM;
=Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance | - 42. 9,10-Dihydroergotamine Mesylate
- [An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release. ( NCI )] (UMLS (NCI) C0700532) =Organic Chemical; Pharmacologic Substance =DIHYDROERGOTAMINE;
=DIHYDROERGOTAMINE MESYLATE 1 MG/ML;
DIHYDROERGOTAMINE MESYLATE 4 MG/ML;
|
- 17. 1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride
- [The hydrochloride salt of the partial estrogen antagonist nafoxidine. Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors. This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue. Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04) ( NCI )] (UMLS (NCI) C0205850) =Organic Chemical; Pharmacologic Substance
| - 43. DIHYDROERGOTAMINE
- [A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS. ( MSH )] (UMLS (NCI) C0012291) =Organic Chemical; Pharmacologic Substance =[CN105] ANTIMIGRAINE AGENTS;
Ergotamine Derivatives =9,10-Dihydroergotamine Mesylate |
- 18. 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide
- [A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses. ( NCI )] (UMLS (NCI) C0069751) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
5H-Dibenz(b,f)azepine-5-carboxamide =OXCARBAZEPINE 300 MG;
OXCARBAZEPINE 600 MG;
OXCARBAZEPINE 150 MG;
OXCARBAZEPINE 300 MG/5ML | - 44. dihydronicotinamide adenine dinucleotide
- [coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage; found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). ( CSP )] (UMLS (CSP) C0027270) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
=adenine nucleotide;
cofactor;
high energy compound;
nicotinamide ribotide |
- 19. 17,21-Dihydroxypregn-4-ene-3,11,20-trione
- [naturally occurring glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory agent; cortisone itself is inactive and is converted in the liver to the active metabolite cortisol. ( CSP )] (UMLS (NCI) C0010137) =Steroid; Pharmacologic Substance; Hormone ;
=[HS051] GLUCOCORTICOIDS;
Pregnenes =21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione;
CORTISONE 25 MG;
| - 45. dihydropyridine receptor
- [ ] (UMLS (CSP) C0218111) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 20. 2,3-Dihydro-1H-imidazo(1,2-b)pyrazole
- [A synthetic agent, also known as IMPY, with antineoplastic properties. IMPY inhibits ribonucleotide reductase, an enzyme that converts ribonucleotides to deoxyribonucleotides during DNA synthesis; this agent specifically binds the smaller, nonheme-iron subunit of the enzyme. (NCI04) ( NCI )] (UMLS (NCI) C0045368) =Organic Chemical; Pharmacologic Substance ;
| - 46. Dihydropyrimidine Dehydrogenase
- [An enzyme involved in pyrimidine catabolism. Increased DPD levels can influence tumor response to 5-fluorouracil-based chemotherapy through increased inactivation of the agent in tumor cells. Increases of the DPD mRNA level in cancerous tissue seem to reflect tumor progression. High DPD mRNA levels in liver metastasis and advanced colorectal cancer may have clinical importance for 5-fluorouracil-based chemosensitivity. (from Ann Surg Oncol 2002;9:599-603) ( NCI )] (UMLS (NCI) C0058126) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 21. 2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine
- [potent long acting orally effective vasodilator, acting mainly on arterioles, used as an antihypertensive; also applied topically in the treatment of male pattern baldness of the vertex. ( CSP )] (UMLS (NCI) C0026196) =Organic Chemical; Pharmacologic Substance =antihypertensive agent;
Piperidines;
Pyrimidine;
[CV490] ANTIHYPERTENSIVES, OTHER;
DAP;
[DE900] DERMATOLOGICALS, TOPICAL OTHER =MINOXIDIL 10 MG;
MINOXIDIL 2.5 MG;
MINOXIDIL 2 %;
MINOXIDIL 5 %;
| - 47. Dihydropyrimidine Dehydrogenase Gene
- [This gene is involved in pyrimidine catabolism. ( NCI )] (UMLS (NCI) C1366555) DPYD;
DPYD Gene =Gene or Genome |
- 22. 2,3-Dihydroxy-2-(1-methylethyl)butanoic Acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl Ester N-Oxide
- [A natural pyrrolizidine alkaloid with antineoplastic properties. Indicine-N-oxide alkylates and crosslinks DNA. (NCI04) ( NCI )] (UMLS (NCI) C0063465) =Organic Chemical; Pharmacologic Substance ;
| - 48. DIHYDROSTREPTOMYCIN
- [A derivative of streptomycin, aminoglycoside antibiotic, with bactericidal property. Dihydrostreptomycin depends on active transport across the bacterial cell membrane before irreversibly binding S12 protein of the bacterial 30S ribosomal subunit. As a result, this agent interferes with the initiation complex between messenger RNA and the bacterial ribosome thereby causing the misreading of the genetic code resulting in the production of non-functional proteins, consequently leading to bacterial cell death. ( NCI )] (UMLS (NCI) C0262967) =Carbohydrate; Antibiotic
|
- 23. 2,3-Dihydroxybutanedioic Acid
- [A white crystalline dicarboxylic acid found in many plants, particularly tamarinds and grapes. Tartaric acid is used to generate carbon dioxide through interaction with sodium bicarbonate following oral administration. Carbon dioxide extends the stomach and provides a negative contrast medium during double contrast radiography. In high doses, this agent acts as a muscle toxin by inhibiting the production of malic acid, which could cause paralysis and maybe death. ( NCI )] (UMLS (NCI) C0075821) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid; Hazardous or Poisonous Substance =tartrate;
Inactive Ingredient Preparations =STANNOUS TARTRATE;
TARTARIC;
DIPYRIDAMOLE 5 MG INTRAVENOUS INJECTION;
TARTARIC ACID PWDR;
TARTARIC ACID 0.42 GM | - 49. Dihydrostreptomycin Sequisulphate
- [A semi-synthetic aminoglycoside antibiotic with bactericidal properties. Dihydrostreptomycin sulfate inhibits protein synthesis by binding to the 30S ribosomal subunit. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tulemia. ( NCI )] (UMLS (NCI) C0012317) =Carbohydrate; Antibiotic
|
- 24. 2,4-dihydroxy-5-methylpyrimidine
- [2,4-diketo-5-methylpyrimidine; one of the 5 major bases (with adenine, guanine, cytosine, and uracil) found in nucleic acids. ( CSP )] (UMLS (NCI) C0040087) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance ;
=Pyrimidine;
nucleobase | - 50. Dihydrouracil Dehydrogenase Deficiency
- (UMLS (NCI) C0268132) =Disease or Syndrome ;
|
- 25. 2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one
- [antioxidant flavonol widely distributed in plants. ( CSP )] (UMLS (NCI) C0034392) =Organic Chemical; Pharmacologic Substance; Vitamin =flavonoid;
vasoactive agent | - 51. dihydroxyacetone
- [ketotriose compound; its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage; it is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes; in combination with naphthoquinones it acts as a sunscreening agent. ( CSP )] (UMLS (CSP) C0012322) =Carbohydrate; Pharmacologic Substance; Biomedical or Dental Material =Ketoses;
triose;
[DE900] DERMATOLOGICALS, TOPICAL OTHER;
=DIHYDROXYACETONE 5 % |
- 26. 2-(3,4-Dihydroxyphenyl)ethanol
- (UMLS (NCI) C0376776) =Organic Chemical; Pharmacologic Substance ;
| - 52. dihydroxyphenylalanine
- [D1 and D2 agonist; precursor in dopamine biosynthesis; levodopa or L-DOPA is the generic name of the antiparkinson drug. ( CSP )] (UMLS (CSP) C0013023) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Neuroreactive Substance or Biogenic Amine =[CN500] ANTIPARKINSON AGENTS;
catecholamine;
phenylalanine;
Dopamine Agonist =(--)-2Amino-3-)3,4-dihydroxyphenyl)propanoic Acid;
3-Hydroxy-alpha-methyl-L-tyrosine;
|
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