UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
E E0 E6 E7 EA EB EC ED EE EF EG EH EI EJ EK EL EM EN EO EP EQ ER ES ET EU EV EW EX EY
ENA ENC END ENE ENG ENH ENI ENK ENL ENM ENN ENO ENP ENR ENT ENU ENV ENZ
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1. (E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine-hydrochloride
[The hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved. ( NCI )] (UMLS (NCI) C0304594) =Organic Chemical; Pharmacologic Substance =naftifin;
=NAFTIFINE HYDROCHLORIDE 1 %

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