- 1. VAV
- [VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and two zinc finger-like domains. VAV also has an SH2, two SH3, and a guanosine exchange factor domain. Truncation of its N-terminus, containing an HLH domain and leucine zipper, activates its oncogenic potential. Wild type VAV is transcribed in hematopoietic cells, including erythroid, lymphoid, and myeloid lineages. VAV-dependent signaling pathways regulate the maturation of T-cells. (from OMIM 164875 and NCI) ( NCI )] (UMLS (NCI) C1451772) VAV1;
VAV1 Gene Product;
VAV1 Protein;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 5. VAV Family Gene
- [VAV Family Genes (VAV1, VAV2, and VAV3) encode VAV proteins that respond to similar cell surface receptor tyrosine kinases as GEFs for Rho/Rac family GTPases, which activate pathways leading to actin cytoskeletal rearrangements, transcriptional alterations, cell differentiation, and/or cell proliferation. VAV proteins contain CH, DH, PH, SH2, SH3, and zinc-dependent phorbol-ester and DAG binding domains. VAV1 is expressed exclusively in hematopoietic cells, while VAV2 and VAV3 are more broadly expressed. (NCI) ( NCI )] (UMLS (NCI) C1336928) =Gene or Genome
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- 2. VAV 1 Oncogene Gene
- [This gene plays a role in signal transduction. It is involved in the development and activation of both B cells and T cells. ( NCI )] (UMLS (NCI) C1336926) VAV1;
VAV1 Gene;
=Gene or Genome | - 6. VAV2
- [A member of the VAV oncogene family, VAV2 is a probable exchange factor for a RAS-like GTP-binding protein and responds to a cell surface receptor tyrosine kinase. Integrin-induced phosphorylation of VAV2 requires SYK. VAV2 contains a calponin-homology domain, a DBL-homology domain, a PH domain, a DAG binding domain, an SH2 domain, and SH3 domains. (from OMIM 600428 and NCI) ( NCI )] (UMLS (NCI) C0297681) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 3. VAV 2 Oncogene Gene
- [This gene plays a role in signal transduction and negative regulation of T-cell activation. ( NCI )] (UMLS (NCI) C0812239) VAV2;
VAV2 Gene =Gene or Genome | - 7. VAV3
- [Encoded by human VAV3 Gene (VAV Family), the 847-amino acid VAV-3 Protein exhibits similarity to VAV1 and VAV2. Alpha and beta isoforms are expressed in peripheral blood lymphocytes, spleen, brain, thymus, heart, kidney, liver, placenta, and lung. VAV3 contains DBL and pleckstrin homology domains, a calponin homology region, an acidic motif, a DAG binding domain, two SH3 regions, and a SH2 domain. VAV3.1 Protein variant contains only the C-terminal SH3-SH2-SH3 region. Regulating the actin cytoskeleton and transcription, VAV3 acts as a GEF on RHOA, RHOG, and RAC1. VAV1, VAV2, and VAV3 respond to similar cell surface receptor tyrosine kinases. VAV3 is rapidly phosphorylated on TCR or EGFR activation. VAV1 and VAV3 enhance NFKB-dependent transcription. Integrin-induced phosphorylation requires SYK. (OMIM, Swiss-Prot, LocusLink, and NCI) ( NCI )] (UMLS (NCI) C0904737) VAV3 Protein;
VAV-3 Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 4. VAV 3 Oncogene Gene
- [This gene plays a role in signal transduction and modulation of cell morphology. It is also involved in the regulation of platelet activation. ( NCI )] (UMLS (NCI) C1336927) VAV3;
VAV3 Gene;
=Gene or Genome | |
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