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4-Thiazolidine Carboxylic Acid
[A cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activity. Thiazolidine carboxylic acid (TCA) acts on cellular membranes of malignant cells through an unknown mechanism to induce reverse transformation, a term denoting changes in morphological and growth characteristics that cause malignant cells to revert back to an untransformed state. TCA produces anti-proliferative effects by restoring contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, which is presumably the result of cell-to-cell signal transfer. This drug may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations, an important protective property useful against DNA-damaging agents, including chemotherapy and radiation. ( NCI )]
UMLS (NCI) C0076425- Organic Chemical
- Pharmacologic Substance
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