[A third generation semisynthetic cephalosporin antibiotic with bactericidal activity. Cefotaxime inhibits mucopeptide synthesis by binding to and inactivating penicillin binding proteins thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of bacterial cell walls. This results in a reduction of cell wall stability and causes cell lysis. ( NCI )]
UMLS (NCI) C0007554 - Organic Chemical
- Antibiotic
Relation/PAR: Cephacetrile
[AM103] CEPHALOSPORINS, 3RD GENERATION
Relation/CHD: CEFTIZOXIME
CEFTRIAXONE
CEFUROXIME
CEFIXIME
CEFOTAXIME SODIUM