Calcium-Activated Chloride Channel-2
[Encoded by human CLCA2 Gene (similar to CLCA1), the 943-amino acid Calcium-Activated Chloride Channel-2 (CLCA Family) is expressed in trachea, lung, and mammary gland and displays outward rectifying anion conductance. Family members differ in tissue distribution. CLCA2 protein contains a large N-terminal extracellular domain containing conserved cysteines, five transmembrane domains, a monobasic proteolytic cleavage consensus site, potential glycosylation sites, and potential PKC phosphorylation sites. Nascent CLCA2 may be cleaved into 86 kD N-terminal, and 34 kD C-terminal, polypeptides associated with the cell surface. CLCA2 may play a role in the pathogenesis of cystic fibrosis and in cancer metastasis to the lung, mediating vascular arrest and colonization. CLCA2 has been implicated as a tumor suppressor for breast cancer. (from SWISS-PROT, OMIM, and NCI) ( NCI )]
UMLS (NCI) C1332834Calcium-Sensitive Chloride Channel 2
Chloride Channel, Calcium Activated, Family Member 2 Protein
CLCA2
Chloride Channel, Calcium Activated, Family Member 2 Protein
CLCA2
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
Buy website
Medical Clinic. Optician. Pharmacy. Physician. Travel Agency. Hotel reservation. Child Care. Education. Teachers. Lessons. Tests and Exams. Certification. Shopping Center. Store. Real Estate.Affordable prices from $100.
  |
home
