[HMGN1 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN1 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995 Aug;6(4):247-55) ( NCI )]
UMLS (NCI) C0019797 - Amino Acid, Peptide, or Protein
- Biologically Active Substance