ENL
[Encoded by human MLLT1 Gene, 559-aa 62-kDa nuclear ENL Protein is similar to MLLT3/AF9 (Human), TFG3/ANC1 (Yeast), and trithorax (Drosophila), contains nuclear targeting sequences, serine- and proline-rich regions, and stretches abundant in basic amino acids, and appears capable of transcriptional transactivation in lymphoid and myeloid cells. The C-terminal 90-aa of MLLT1 are required for activation of transcription. A common acute leukemia chromosomal translocation t(11;19)(q23;p13.3) involves MLL/HRX and MLLT1 that results in a rogue chimeric activator protein containing the MLL N-terminal AT-hook motifs. (NCI) ( NCI )]
UMLS (NCI) C1333335ENL Protein
MLLT1
Trithorax Homolog 1
MLLT1
Trithorax Homolog 1
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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