P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
PLZF-RARA Chimera
[Translocation t(11;17)(q23;21) fuses the PLZF gene on 11q23.1 to the RARA gene on chromosome 17 producing a 'dominant-negative' PLZF-RARA fusion protein in myeloid cells and resulting in APL. The oncogenic retinoic acid receptor mediates leukemogenesis through aberrant chromatin acetylation. Through the RAR-alpha CoR box, PLZF-RAR-alpha fusion proteins recruit the NCOR/histone deacetylase complex. (from OMIM 176797 and NCI) ( NCI )]
UMLS (NCI) C0765587PLZF-RARalpha
Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha Chimera
ZNF145/RARA Chimera
Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha Chimera
ZNF145/RARA Chimera
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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