TAL2

1. [This gene is involved in transcriptional regulation. It plays a role in T-cell acute lymphocytic leukemia. ( NCI )]
   UMLS (NCI) C1336574
   
   TAL2 Gene
   T-Cell Acute Lymphocytic Leukemia 2 Gene
    

   Gene or Genome
   

2. [Encoded by human TAL2 Gene, 108-aa 12-kDa bHLH T-Cell Acute Lymphocytic Leukemia 2 Protein has sequence homology to TAL1 and LYL1, bHLH proteins involved in T-cell leukemogenesis. TAL2 also includes a DNA-binding domain homologous to those in TAL1 and LYL1. A T-ALL translocation, t(7;9)(q34;q32), results from a mistake during V(D)J recombination using a fortuitous 3-prime TAL2 recombination site and the TCRB J-beta-2 coding segment that juxtaposes TAL2 with the TCR-beta enhancer and results in TAL2 overexpression. (NCI) ( NCI )]
   UMLS (NCI) C1447263
   
   TAL2 Protein
   T-Cell Acute Lymphocytic Leukemia 2
   T-Cell Acute Lymphocytic Leukemia 2 Protein
   
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance