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TF (c)-KLH conjugate vaccine
[A vaccine containing a clustered pancarcinoma carbohydrate antigen, Thomsen-Friedenreich (TF) antigen, conjugated with keyhole limpet hemocyanin (KLH) with potential antineoplastic activity. TF antigen is a disaccharide epitope (galactose-beta1-3-N-acetylgalactose), normally O-linked to serine or threonine of tumor associated epithelial mucins. This vaccine contains the TF epitope cluster (c) that is synthesized by linking 3 copies of the TF epitope on a threonine backbone to achieve the essential immunogenic structure. KLH is a hapten carrier and serves as an immunostimulant to improve immune recognition. Vaccination with TF(c)-KLH peptide vaccine may produce antibodies and elicit a cytotoxic T lymphocyte (CTL) response against those tumor cells expressing TF antigen, resulting in decreased tumor growth. ( NCI )]
UMLS (NCI) C0796636TF(c)-KLH
TF(c)-KLH Conjugate Vaccine
vaccine, TF (c)-KLH conjugate
vaccine, TF(c)-KLH conjugate
TF(c)-KLH Conjugate Vaccine
vaccine, TF (c)-KLH conjugate
vaccine, TF(c)-KLH conjugate
- Pharmacologic Substance
- Immunologic Factor
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