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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
C C- C1 C3 C5 C6 C7 CA CB CC CD CE CF CG CH CI CJ CK CL CM CN CO CP CQ CR CS CT CU CV CW CX CY CZ
CA CA CA1 CA2 CA4 CAA CAB CAC CAD CAE CAF CAG CAH CAI CAL CAM CAN CAO CAP CAR CAS CAT CAU CAV CAY

cathepsin D

[Cathepsin D, encoded by the CTSD Gene, is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It has a specificity similar to but narrower than that of pepsin A, decomposing cytoplasmic proteins, cell organelles, collagen, elastase and proteoglycans. Cathepsin D takes part in angiogenesis and activates osteoclasts, and plays a major role in the destruction of bone tissue by cholesteatoma. Transcription of the CTSD gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast and ovarian cancer, and possibly Alzheimer disease. (From LocusLink, PMID 12185597 and NCI) ( NCI )]
UMLS (CSP) C0007427
 
Amino Acid, Peptide, or Protein
Enzyme
Relation/PAR: aspartate protease

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