- 1. bcl 1 gene
- [The B-cell leukemia/lymphoma-1 genes, associated with various neoplasms when overexpressed. Overexpression results from the t(11;14) translocation, which is characteristic of mantle zone-derived B-cell lymphomas. The human c-bcl-1 gene is located at 11q13 on the long arm of chromosome 11. ( MSH )] (UMLS (CSP) C0525036) =Gene or Genome ;
| - 8. BCL2-Like 1, Long Isoform
- [Like bcl-2 bcl-xL acts as a repressor of apoptosis. bcl-xL mediates the closure of the mitochondrial porin channel VDAC and thus regulates the release of cytochrome c during apoptosis. ( NCI )] (UMLS (NCI) C0288330) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 2. BCL-1 Rearrangement
- (UMLS (NCI) C1317175) CCND1 Gene Rearrangement;
Clonal BCL-1 Gene Rearrangement;
Clonal CCND1 Gene Rearrangement;
Monoclonal BCL-1 Gene Rearrangement =Genetic Function; ;
| - 9. BCL2-Like 1, Short Isoform
- [bcl-xS has been shown to inhibit the ability of bcl-2 and bcl-xL to enhance the survival of cells. ( NCI )] (UMLS (NCI) C0288331) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 3. BCL-2 Binding Protein
- [Found only in the cytosol, TP53BP2 impedes cell cycle progression beyond G2/M. It enhances p53 trans-activation function and induces p21 (CDKN1A) expression. TP53BP2 contains ankyrin repeats and an SH3 domain, required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously. (from OMIM 602143 and NCI) ( NCI )] (UMLS (NCI) C0290923) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 10. BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like Gene
- [This gene is involved in the regulation of apoptosis and induces cell death. ( NCI )] (UMLS (NCI) C1332435) BNIP3L;
BNIP3L Gene;
=Gene or Genome ;
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- 4. BCL-2 Gene Family
- [The BCL-2 Gene Family encodes proteins that contain Bcl-2 homology (BH) domains (1, 2, 3, or 4), involved in interactions among apoptotic protein factors that participate in programmed cell death. ( NCI )] (UMLS (NCI) C1332391) =Gene or Genome ;
| - 11. BCL2L1
- [A member of the bcl-2 protein family that plays a role in the regulation of APOPTOSIS. Two major isoforms of the protein exist due to ALTERNATIVE SPLICING of the BCL2L1 mRNA and are referred to as Bcl-XS and Bcl-XL. ( MSH )] (UMLS (NCI) C0219472) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
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- 5. BCL1
- [Essential for control of the G1/S transition, cyclin D1 interacts with CDK4 and CDK6 to form a serine/threonine kinase holoenzyme and imparts substrate specificity to the complex. RB regulates cyclin D1 gene expression. Cyclin D1 expression may identify Barrett's esophagus patients at high risk for esophageal carcinoma; risk of progression to adenocarcinoma exhibits an odds ratio of 6.85. The BCL1 and PRAD1 oncogenes involve cyclin D1 gene translocations. (from J Natl Cancer Inst 2000. 92:1282 & 1316, SWISS-PROT P24385, OMIM 168461, and NCI) ( NCI )] (UMLS (NCI) C0174680) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 12. BCL2L1
- [This gene is an apoptotic regulator that can have anti or pro apoptotic effects. ( NCI )] (UMLS (NCI) C1332397) BCL2L1 Gene;
BCL2-Like 1 Gene;
=Gene or Genome ;
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- 6. BCL2 gene/protein
- [over-production has been shown to make tumor cells strikingly more resistant to cell death induced by nearly all chemotherapeutic drugs and radiation, suggesting that it may be viewed as a multidrug- resistant gene. ( CSP )] (UMLS (CSP) C0872308) =Classification ;
=Cellular Oncogene;
| - 13. BCL2L11
- [This gene is involved in the regulation of apoptosis and promotes cell death. ( NCI )] (UMLS (NCI) C1337096) BCL2L11 Gene;
BCL2-like 11 (Apoptosis Facilitator) Gene;
=Gene or Genome ;
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- 7. BCL2-Interacting Killer Gene
- [This gene is involved in the regulation of apoptosis and induces apoptotic activity. ( NCI )] (UMLS (NCI) C1332411) BIK;
BIK Gene;
=Gene or Genome ;
| - 14. BCL2L2
- [This gene is involved in the regulation of apoptosis. Expression of BCL2L2 gene inhibits cellular apoptosis under cytotoxic conditions. ( NCI )] (UMLS (NCI) C1332398) BCL2L2 Gene;
BCL2-Like 2 Gene;
=Gene or Genome ;
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