- 1. (+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione
- [DNA topoisomerase I inhibitor. ( CSP )] (UMLS (NCI) C0123931) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS; (+)-Camptothecin; enzyme inhibitor; =Irinotecan Hydrochloride | - 3. (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'
6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride - [An oral formulation of hydrochloride salt of topotecan, a semisynthetic derivative of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Compared to intravenously administered topotecan, the oral formulation is a more convenient way of administering this agent. ( NCI )] (UMLS (NCI) C0886549) Hycamptamine;
Oral Topotecan Hydrochloride; Topotecan HCl; Topotecan hydrochloride; topotecan hydrochloride (oral); TOPOTECAN HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance ; =(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione; =TOPOTECAN HYDROCHLORIDE 4 MG |
- 2. (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
- [antineoplastic drug which acts as a DNA topoisomerase inhibitor. ( CSP )] (UMLS (NCI) C0146224) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS; (+)-Camptothecin =(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4' 6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride | - 4. (S)-dihydroorotate:oxygen oxidoreductase
- [A flavoprotein (FAD, FMN). Catalyzes the reaction of S-dihydroorotate and oxygen into orotate and hydrogen peroxide. Ferricyanide can act as acceptor. [EC 1.3.3.1 created 1961] (from IUBMB) ( NCI )] (UMLS (NCI) C0058099) =Amino Acid, Peptide, or Protein; Enzyme ;
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