- 1. (Z)-1-(2-(2,4-Dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1H-imidazole Mononitrate
- [The nitrate salt form of oxiconazole, a synthetic imidazole derivative with an antifungal activity. Oxiconazole nitrate inhibits cytochrome P-450 dependent C-14 alpha demethylation of fungal sterols, which results in accumulation of 14 alpha-methyl sterols, inhibition of ergosterol synthesis, disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. ( NCI )] (UMLS (NCI) C0142160) =Organic Chemical; Pharmacologic Substance
| - 8. ZD0473
- [A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called platinum analogs. ( NCI )] (UMLS (NCI) C0671137) =Organic Chemical; Pharmacologic Substance
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- 2. (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate
- [The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, thereby inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma as well as in other cancers that express high levels of protein kinase C. ( NCI )] (UMLS (NCI) C0079589) =Organic Chemical; Pharmacologic Substance =1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene;
=TAMOXIFEN CITRATE 10 MG;
TAMOXIFEN CITRATE 20 MG | - 9. ZD1694
- (UMLS (NCI) C0950790) =Organic Chemical; Pharmacologic Substance
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- 3. 2-[4-[(1Z)-1,2-Diphenyl-1-butenyl]phenoxy]-N-methylethanamine
- (UMLS (NCI) C0067934) =Organic Chemical; Biologically Active Substance
| - 10. ZD2767
- [A phenol mustard glutamate prodrug which induces apoptosis by cross-linking DNA and with potential use in Antibody Directed Enzyme Prodrug Therapy (ADEPT). (NCI) ( NCI )] (UMLS (NCI) C0385704) =Organic Chemical; Pharmacologic Substance ;
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- 4. Z DNA
- [zigzag left-handed conformer of DNA; naturally occurring Z DNA is sensitive to a different set of enzymes and binding proteins than "normal" B DNA, and is thought to play an important role in genetic regulation. ( CSP )] (UMLS (CSP) C0043442) =Nucleic Acid, Nucleoside, or Nucleotide; Biologically Active Substance =deoxyribonucleic acid;
| - 11. ZD4054
- [An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. ZD4054 binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation. (NCI05) ( NCI )] (UMLS (NCI) C1328193) =Organic Chemical; Pharmacologic Substance ;
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- 5. Z-DNA Binding Protein
- [A protein which specifically binds to Z DNA ( NCI )] (UMLS (NCI) C1337041) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 12. ZD6126
- [A water-soluble phosphate prodrug of N-acetylcolchinol with potential antineoplastic activity. ZD-6126 binds to and destabilizes the tubulin cytoskeleton of endothelial cells, thereby inhibiting angiogenesis which may result in tumor necrosis. (NCI04) ( NCI )] (UMLS (NCI) C1122629) ZD-6126 =Organic Chemical; Pharmacologic Substance ;
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- 6. ZD 1839
- (UMLS (NCI) C0879396) ZD1839 =Organic Chemical; Pharmacologic Substance ;
| - 13. ZDX
- (UMLS (NCI) C0149473) =Amino Acid, Peptide, or Protein; Pharmacologic Substance
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- 7. ZD-1033
- (UMLS (NCI) C0290882) =Organic Chemical; Pharmacologic Substance ;
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