(3R,5S,6E)-(+/-)-7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic Acid
[The sodium salt of a synthetic lipid-lowering agent with potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. ( NCI )]
UMLS (NCI) C0246203- Organic Chemical
- Pharmacologic Substance
Relation/PAR: FLUVASTATIN
Relation/CHD: FLUVASTATIN SODIUM 20 MG
FLUVASTATIN SODIUM 40 MG
FLUVASTATIN SODIUM 80 MG
FLUVASTATIN SODIUM 40 MG
FLUVASTATIN SODIUM 80 MG
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