2-F-ara-AMP
[The phosphate salt of fludarabine, a synthetic purine nucleoside antimetabolite with antineoplastic activity. Preferentially transported into malignant cells and metabolized to its active form 2-fluoro-ara-ATP by deoxycytidine kinase, fludarabine inhibits alpha DNA polymerase and RNA reductase and competes with deoxyadenosine triphosphate, resulting in inhibition of DNA primase, inhibition of DNA synthesis, and cell death. (NCI04) ( NCI )]
UMLS (NCI) C0060483- Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance
Relation/PAR: 2-Fluoro-9-beta-arabinofuranosyladenine
Relation/CHD: FLUDARABINE PHOSPHATE 50 MG
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