- 1. F31 grant
- [ ] (UMLS (CSP) C1656584) =Intellectual Product ;
| - 21. FGF7
- [This gene plays a role in cellular biogenesis, growth, organization and proliferation. It is also involved in the inhibition of apoptosis. ( NCI )] (UMLS (NCI) C0919507) FGF7 Gene;
Fibroblast Growth Factor 7 (Keratinocyte Growth Factor) Gene;
=Gene or Genome ;
|
- 2. F32 grant
- [ ] (UMLS (CSP) C1656055) =Intellectual Product
| - 22. FGF8
- [This gene is involved in development and organogenesis. ( NCI )] (UMLS (NCI) C1333539) FGF8 Gene;
Fibroblast Growth Factor 8 (Androgen-Induced) Gene =Gene or Genome ;
|
- 3. FG
- [A country in Northern South America, bordering the North Atlantic Ocean, between Brazil and Suriname. (NCI) ( NCI )] (UMLS (NCI) C0016703) =Geographic Area ;
| - 23. FGF9
- [Expressed in glia and neurons by human FGF9 Gene (FGF family), 208-aa 23-kDa (precursor) N-glycosylated monomeric secreted Fibroblast Growth Factor 9 has glial growth-stimulating effects and is likely involved in glial cell growth and differentiation, gliosis, and differentiation or survival of neuronal cells. Three molecular species of 30-kDa, 29-kDa and 25-kDa, cleaved at Leu-4, Val-13 and Ser-34 respectively, are found. Expression may be dependent on Sonic hedgehog signaling. (NCI) ( NCI )] (UMLS (NCI) C0386595) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 4. FGF Receptor
- [Family of receptor tyrosine kinases for fibroblast growth factor. Amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. ( NCI )] (UMLS (NCI) C0060369) =Amino Acid, Peptide, or Protein; Receptor ;
| - 24. FGF9
- [This gene plays a role in the promotion of cellular growth/proliferation and negative regulation of apoptosis. It is also involved in glial cell development. ( NCI )] (UMLS (NCI) C1333540) FGF9 Gene;
Fibroblast Growth Factor 9 (Glia-Activating Factor) Gene =Gene or Genome ;
|
- 5. FGF Receptor Activating Protein 1
- [Encoded by human FRAG1 Gene, FGF Receptor Activating Protein 1 appears to be a 315-aa 36-kDa membrane-spanning protein whose function is not currently known. FRAG1 resides in a chromosome region implicated in Beckwith-Wiedemann syndrome and frequent loss of heterozygosity in multiple tumor types. (from Proc Natl Acad Sci 1996;93:8956-61 and Genomics 1999;62:59-66) ( NCI )] (UMLS (NCI) C1313485) FRAG1;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 25. FGFR Signaling Adaptor
- [Encoded by human FRS2 Gene, 508-aa 56.8-kD FGFR Substrate 2 contains a myristylation sequence, a PTB domain, and 4 potential GRB2/SHP2-binding sites. FGFR-mediated Tyr-phosphorylated FRS2 binds to FGFR1 and GRB2/SOS in response to FGF or NGF. An FGFR1 juxtamembrane segment and the PTB domain appear to interact and mediate FRS Tyr phosphorylation. Myristylation is essential for FRS2 membrane localization, Tyr phosphorylation, GRB2/SOS recruitment, and MAPK activation. FRS2A is Thr phosphorylated by MAPK in response to FGF, insulin, EGF, and PDGF. FRS2 may function as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF to link receptor activation with MAPK and other pathways essential for cell growth and differentiation. (NCI) ( NCI )] (UMLS (NCI) C0540129) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
|
- 6. FGF1
- [This gene plays a role in angiogenesis and organogenesis. It is also involved in the regulation of endothelial cell migration and proliferation. ( NCI )] (UMLS (NCI) C1333536) FGF1 Gene;
Fibroblast Growth Factor 1 (Acidic) Gene =Gene or Genome ;
| - 26. FGFR Substrate 3
- [Encoded by human FRS3 Gene, 492-aa 54-kDa plasma membrane-associated FGFR Substrate 3 is an FGFR substrate that links FGFR stimulation to RAS activators. Similar (49% identical) to FRS2, FRS3 also contains a myristylation sequence, a PTB domain, and Tyr-containing motifs that govern GRB2 and SHP2 recruitment. FRS2 and FRS3 bind directly to FGFR1; an FGFR1 juxtamembrane segment and the PTB domain appear to interact and mediate FRS Tyr phosphorylation. (NCI) ( NCI )] (UMLS (NCI) C1333545) Fibroblast Growth Factor Receptor Substrate 3;
FRS2B;
FRS2-Beta;
FRS3;
SNT2;
SUC1-Associated Neurotrophic Factor Target 2 =Amino Acid, Peptide, or Protein; Biologically Active Substance |
- 7. FGF10
- [This gene is involved in development and wound healing. It also plays a role in cellular biogenesis, organization and proliferation. ( NCI )] (UMLS (NCI) C1333535) FGF10 Gene;
Fibroblast Growth Factor 10 Gene =Gene or Genome ;
| - 27. FGFR1
- [Acidic fibroblast growth factor stimulates tyrosine kinase activity of FGFR1, the receptor for acidic FGF. The receptor is a transmembrane protein that contains three extracellular Ig-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain. (from OMIM 136350 and NCI) ( NCI )] (UMLS (NCI) C0170936) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
|
- 8. FGF2
- [This gene is involved in angiogenesis, development and cell cycle control. ( NCI )] (UMLS (NCI) C0919506) FGF2 Gene;
Fibroblast Growth Factor 2 (Basic) Gene;
=Gene or Genome ;
| - 28. FGFR1
- [This gene plays a role in mitogenesis and differentiation. ( NCI )] (UMLS (NCI) C0919509) FGFR1 Gene;
Fibroblast Growth Factor Receptor 1 (FMS-Related Tyrosine Kinase 2, Pfeiffer Syndrome) Gene;
=Gene or Genome ;
|
- 9. FGF20
- [Expressed in brain by human FGF20 Gene (FGF Family), 211-aa 23.5-kDa Fibroblast Growth Factor 20 contains a strong hydrophobic region in its FGF core domain and a weak hydrophobic N terminal region. FGF20 may enhance the survival of midbrain dopaminergic neurons. (NCI) ( NCI )] (UMLS (NCI) C0962069) Fibroblast Growth Factor 20;
=Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 29. FGFR1 Oncogene Partner
- [Encoded by human FGFR1OP Gene, ubiquitous 399-aa 43-kDa hydrophilic FGFR1 Oncogene Partner protein contains N- and C-terminal alpha helices harboring leucine-rich repeats. FOP may play a role in erythroid cell proliferation and differentiation. (NCI) ( NCI )] (UMLS (NCI) C0764082) Fibroblast Growth Factor Receptor 1 Oncogene Partner;
FOP =Amino Acid, Peptide, or Protein; Receptor ;
|
- 10. FGF20
- [This gene plays a role in development, cell growth, morphogenesis and tissue repair. ( NCI )] (UMLS (NCI) C1333537) FGF20 Gene;
Fibroblast Growth Factor 20 Gene =Gene or Genome ;
| - 30. FGFR1 Oncogene Partner Gene
- [This gene is involved in the regulation of cell shape, polarity and motility. ( NCI )] (UMLS (NCI) C1333541) FGFR1OP;
FGFR1OP Gene =Gene or Genome ;
|
- 11. FGF21
- [Fibroblast Growth Factor 21 (209-aa 22-kDa precursor) is encoded by human FGF21 Gene (FGF Family). FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. (NCI) ( NCI )] (UMLS (NCI) C0972232) Fibroblast Growth Factor 21 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 31. FGFR2
- [KGF is a potent mitogenic paracrine mediator of epithelial cell proliferation. The keratinocyte growth factor receptor is a FGFR RTK family member with three extracellular Ig-like domains, a single membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. Two alternatively spliced FGFR2 gene products, KGFR and BEK, vary in sequence within the third extracellular Ig loop, which influence ligand-binding characteristics. Control of these alternative splice sites is thought to involve transacting factors. These receptors also have different patterns of expression. KGFR appears to have a role in skin development; BEK is preferentially expressed in osteogenesis. Dimerization of the FGFR2 ectodomain is induced by binding to FGF1 and a heparin decasaccharide, essential in FGF signaling. (from OMIM 176943 and NCI) ( NCI )] (UMLS (NCI) C0209706) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
|
- 12. FGF21
- [This gene plays a role in signal transduction. ( NCI )] (UMLS (NCI) C1333538) FGF21 Gene;
Fibroblast Growth Factor 21 Gene =Gene or Genome ;
| - 32. FGFR2
- [This gene plays a role in mitogenesis and differentiation and mutations in the gene are associated with craniosynostotic syndromes and bone malformations. ( NCI )] (UMLS (NCI) C1333542) FGFR2 Gene;
Fibroblast Growth Factor Receptor 2 Gene =Gene or Genome ;
|
- 13. FGF3
- [Fibroblast Growth Factor 3 is a member of the FGF family. Fibroblast growth factors have been associated with mesoderm induction and FGF3 has a distinct pattern of expression throughout development in vertebrates. FGF3 constitutes a signal for induction of the otic vesicle, the primordium of the inner ear. (from OMIM 164950 and NCI) ( NCI )] (UMLS (NCI) C0208989) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 33. FGFR3
- [This gene plays a role in bone development and maintenance and mutations in the gene are associated with craniosynostosis and several types of skeletal dysplasia. ( NCI )] (UMLS (NCI) C1333543) FGFR3 Gene;
Fibroblast Growth Factor Receptor 3 (Achondroplasia, Thanatophoric Dwarfism) Gene =Gene or Genome ;
|
- 14. FGF3
- [This gene plays a role in the regulation of cell growth. ( NCI )] (UMLS (NCI) C0812290) FGF3 Gene;
Fibroblast Growth Factor 3 (Murine Mammary Tumor Virus Integration Site (v-int-2) Oncogene Homolog) Gene;
=Gene or Genome | - 34. FGFR4
- [Encoded by human FGFR4 Gene (FGFR Family), 802-amino acid 87.9 kD (precursor) type I membrane protein Fibroblast Growth Factor Receptor 4 is a receptor tyrosine kinase with three extracellular Ig-like C2-type domains, a cytoplasmic tyrosine kinase domain, and 55% amino acid identity with FLG (FGFR1) and BEK. FGFR family amino acid sequence is highly conserved; the extracellular domain interacts with FGFs, signaling downstream cascades that influence mitogenesis and differentiation. FGFRs differ in ligand affinities and tissue distribution. Predominantly expressed in lung, FGFR4 expression is distinct from FLG, BEK, and FGFR3. Unlike FGFR1-3, FGFR4 IgIII domain C-terminal half does not vary. Although function is unknown, FGFR4 preferentially binds acidic FGF and FGF19; it does not bind to basic FGF. (from Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0117719) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 15. FGF4
- [Fibroblast Growth Factor 4 is a heparin-binding growth factor with significant homology to human fibroblast growth factors that appears to function in limb development in conjunction with the SHH pathway. (from OMIM 164980 and NCI) ( NCI )] (UMLS (NCI) C0084220) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 35. FGFR4
- [This gene plays a role in mitogenesis and differentiation. ( NCI )] (UMLS (NCI) C1333544) FGFR4 Gene;
Fibroblast Growth Factor Receptor 4 Gene =Gene or Genome ;
|
- 16. FGF4
- [This gene is involved in development and spermatogenesis. ( NCI )] (UMLS (NCI) C0919466) FGF4 Gene;
FGF4 Oncogene;
Fibroblast Growth Factor 4 (Heparin Secretory Transforming Protein 1, Kaposi Sarcoma Oncogene) Gene;
Fibroblast Growth Factor 4 Oncogene;
HSTF1;
Human Stomach Cancer Derived Oncogene;
Kaposi Sarcoma Oncogene;
K-FGF;
Oncogene HST =Gene or Genome ;
| - 36. FGFRL1
- [Encoded by human FGFRL1 Gene (FGFR Family), at 504-aa 54.6-kDa conserved Fibroblast Growth Factor Receptor-Like 1 consists of an extracellular region (containing 3 Ig-like domains), a hydrophobic transmembrane segment, and a cytoplasmic tail lacking a tyrosine kinase domain. This protein may interact with other family members and inhibit growth factor signaling. (NCI) ( NCI )] (UMLS (NCI) C0962882) Fibroblast Growth Factor Receptor-Like 1;
=Amino Acid, Peptide, or Protein; Receptor ;
|
- 17. FGF5
- [A member of the heparin-binding growth factor family, FGF5 is expressed in neonatal brain. Two isoforms (long and short) are produced by alternative splicing. (from OMIM 165190 and NCI) ( NCI )] (UMLS (NCI) C0117720) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 37. FGFRL1
- [This gene plays a role in the regulation of receptor cellular signal transduction. ( NCI )] (UMLS (NCI) C1364012) FGFRL1 Gene;
Fibroblast Growth Factor Receptor-Like 1 wt Gene =Gene or Genome |
- 18. FGF5
- [This gene plays a role in the stimulation of cell proliferation. ( NCI )] (UMLS (NCI) C0919508) FGF5 Gene;
Fibroblast Growth Factor 5 Gene;
=Gene or Genome ;
| - 38. FGR
- [This gene plays a role in the regulation of cell migration and adhesion. ( NCI )] (UMLS (NCI) C0919478) FGR Gene;
Gardner-Rasheed Feline Sarcoma Viral (V-FGR) Oncogene Homolog Gene;
Oncogene FGR =Gene or Genome ;
|
- 19. FGF6
- [This gene is involved in angiogenesis and cell proliferation. ( NCI )] (UMLS (NCI) C0812296) FGF6 Gene;
Fibroblast Growth Factor 6 Gene =Gene or Genome | - 39. FGS (focal glomerular sclerosis)
- [A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE. ( MSH )] (UMLS (CSP) C0017668) =Disease or Syndrome ;
=glomerulonephritis;
|
- 20. FGF6
- [Fibroblast Growth Factor 6 is encoded by the HST2 proto-oncogene and belongs to the heparin-binding growth factor family. FGF6 exhibits strong mitogenic and angiogenic properties and may be expressed by cells with platelet/megakaryocytic differentiation potential. (from Swiss-Prot P10767 and NCI) ( NCI )] (UMLS (NCI) C1448584) FGF-6;
Fibroblast Growth Factor 6;
HBGF-6;
HST-2 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| |
home
