FGFR4
[Encoded by human FGFR4 Gene (FGFR Family), 802-amino acid 87.9 kD (precursor) type I membrane protein Fibroblast Growth Factor Receptor 4 is a receptor tyrosine kinase with three extracellular Ig-like C2-type domains, a cytoplasmic tyrosine kinase domain, and 55% amino acid identity with FLG (FGFR1) and BEK. FGFR family amino acid sequence is highly conserved; the extracellular domain interacts with FGFs, signaling downstream cascades that influence mitogenesis and differentiation. FGFRs differ in ligand affinities and tissue distribution. Predominantly expressed in lung, FGFR4 expression is distinct from FLG, BEK, and FGFR3. Unlike FGFR1-3, FGFR4 IgIII domain C-terminal half does not vary. Although function is unknown, FGFR4 preferentially binds acidic FGF and FGF19; it does not bind to basic FGF. (from Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0117719- Amino Acid, Peptide, or Protein
- Receptor
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