BRF2 Subunit of RNA Polymerase III Transcription Initiation Factor
[RNA Polymerase III Transcription Initiation Factor BRF2, encoded by the BRF2 gene, is a 50-kD protein that is a subunit of RNA polymerase III transcription initiation factor. BRF2 is involved in the nucleation of a polymerase III-specific small nuclear RNA (snRNA) transcription initiation complex. BRF2 does not directly bind DNA but it interacts with the TATA-binding protein (TBP), and they then bind cooperatively to the polymerase III promoter region of snRNA. The BRF2 protein has a zinc ribbon domain and a core domain. The TBP/BRF2 complex does not have strict requirements for sequence motifs outside the TATA box. Arg235 and phe250 of TBP, and repeat 2 of the BRF2 core domain, are necessary for complex formation with DNA. BRF2 also forms a stable complex on the TATA box of the polymerase II-specific adenovirus major late promoter. (from OMIM 607013, LocusLink 55290, and NCI) ( NCI )]
UMLS (NCI) C0962150BRF2, Subunit of RNA Polymerase III Transcription Initiation Factor, BRF1-Like
BRFU
FLJ11052
RNA Polymerase III Transcription Initiation Factor BRF2
TFIIIB50
Transcription Factor IIB-Related Factor
BRFU
FLJ11052
RNA Polymerase III Transcription Initiation Factor BRF2
TFIIIB50
Transcription Factor IIB-Related Factor
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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