CO COA COB COC COD COE COF COG COH COI COK COL COM CON COO COP COQ COR COS COT COU COV COW COX COY COZ
COCA2
[MutL Homolog 1 (MLH1), a 84-kD protein encoded by the MLH1 gene, is part of the multi-subunit BASC complex, which may sense abnormal DNA structures and regulate post-replication repair and mismatch repair. Heterodimeric MLH1 Protein and PMS2 provide repair proficiency on heteroduplex DNAs, as well as insertion/deletion mispairs. MLH1 and MLH3 also heterodimerize. Widely expressed, several alternative splice variants occur in diverse tissue types. Some variants lack exons 6/9, 9, 9/10, 9/10/11, 10/11, 12, 16, or 17. Associated with colon, endometrial, and stomach cancers, the defects in MLH1 are a cause of hereditary non-polyposis colorectal cancer. (NCI) ( NCI )]
UMLS (NCI) C0753876DNA Mismatch Repair Protein MLH1
FCC2
hMLH1 Protein
HNPCC
HNPCC2
MGC5172
Mismatch DNA Repair Protein MLH1
Mismatch Repair Protein MLH1
MLH1
MLH1 Gene Product
MLH1 Protein
MUTL Protein Homolog 1
FCC2
hMLH1 Protein
HNPCC
HNPCC2
MGC5172
Mismatch DNA Repair Protein MLH1
Mismatch Repair Protein MLH1
MLH1
MLH1 Gene Product
MLH1 Protein
MUTL Protein Homolog 1
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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