CYP3A4

[Induced primarily in liver by glucocorticoids, drugs, pesticides, and carcinogens and encoded by human CYP3A4 Gene (Cytochrome P450 IIIA Subfamily), Cytochrome P450 3A4 is a 502-amino acid 57.3-kD membrane-bound ER heme-thiolate monooxygenase. CYP3A4 is involved in an NADPH-dependent electron transport pathway and phase I oxidative metabolism of carcinogens, steroids, fatty acids, and xenobiotics, as well as bioactivation of aflatoxin B(1) to a genotoxic derivative. Activity seems a key predictor of drug responsiveness and toxicity. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]

UMLS (NCI) C1142644

Cytochrome P450 3A4
Cytochrome P450 Nifedipine Oxidase
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3
Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4
Cytochrome P450, Subfamily IIIA, Polypeptide 4
Cytochrome P450PCN1
EC 1.14.14.1
Glucocorticoid-Inducible P450
Nifedipine Oxidase
P450, FAMILY III
P450-3A4
P450-III, Steroid Inducible
P450-III, Steroid-Inducible
Quinine 3-Monooxygenase
Steroid-Inducible P450- III

Amino Acid, Peptide, or Protein
Enzyme

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