HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain
[Major Histocompatibility Complex, Class II, DP Beta 1 is encoded by the HLA-DPB1 gene. HLA-DPB, an HLA class II beta chain paralogue, plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). HLA-DPB is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the HLA-DPB molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. (from LocusLink) ( NCI )]
UMLS (NCI) C0122007- Amino Acid, Peptide, or Protein
- Immunologic Factor
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