UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
H H+ H1 HA HB HC HD HE HF HG HH HI HK HL HM HN HO HP HQ HR HS HT HU HV HX HY HZ
HLA HLC HLD HLF HLI HLS HLT HLU HLV

HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain

[Major Histocompatibility Complex, Class II, DP Beta 1 is encoded by the HLA-DPB1 gene. HLA-DPB, an HLA class II beta chain paralogue, plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). HLA-DPB is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the HLA-DPB molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. (from LocusLink) ( NCI )]
UMLS (NCI) C0122007
 
Amino Acid, Peptide, or Protein
Immunologic Factor


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