- 1. 13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium
- [The chloride salt form of tubocurarine, a naturally occurring curare alkaloid isolated from the bark and stem of Chondodendron tomentosum with a muscle relaxant property. Tubocurarine chloride competes with acetylcholine for the nicotinic receptors at the neuromuscular junction of skeletal muscles, thereby inhibiting the action of acetylcholine and blocking the neural transmission without depolarizing the postsynaptic membrane. This may lead to skeletal muscle relaxation and paralysis. ( NCI )] (UMLS (NCI) C0282372) =Organic Chemical; Pharmacologic Substance ;
=Tubocurare;
=TUBOCURARINE CHLORIDE 3 MG/ML;
| - 15. HDAC4
- [Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. This protein belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. (LocusLink) ( NCI )] (UMLS (NCI) C0910119) HDAC-A;
Histone Deacetylase 4;
Histone Deacetylase A;
=Amino Acid, Peptide, or Protein; Enzyme |
- 2. 3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-
- [pyrazine with antiviral, schistosomicidal and anticarcinogenic properties. ( CSP )] (UMLS (NCI) C0069456) =Organic Chemical; Pharmacologic Substance ;
=thione;
| - 16. HDAC4
- [This gene is involved in chromatin remodeling, repression of gene expression and myoblast differentiation. ( NCI )] (UMLS (NCI) C1333893) HDAC4 Gene;
Histone Deacetylase 4 Gene =Gene or Genome ;
|
- 3. 4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-Tetrahydro-6-methyl-, Hydrochloride,(6aR)-
- [The hydrochloride salt form of apomorphine, a derivative of morphine and non-ergoline dopamine agonist with high selectivity for dopamine D2, D3, D4 and D5 receptors. Apomorphine hydrochloride acts by stimulating dopamine receptors in the nigrostriatal system, hypothalamus, limbic system, pituitary gland, and blood vessels. This enhances motor function, suppresses prolactin release, and causes vasodilation and behavioral effects. Apomorphine hydrochloride is used in the treatment of Parkinson's disease and erectile dysfunction. In addition, apomorphine hydrochloride acts on the chemoreceptor trigger zone and is used as a central emetic in the treatment of drug overdose. ( NCI )] (UMLS (NCI) C0237406) =Organic Chemical; Pharmacologic Substance =apomorphine;
TO BE DELETED INGREDIENT PREPARATIONS =APOMORPHINE HYDROCHLORIDE 6 MG;
| - 17. HDAC5
- [This gene plays a role in chromatin remodeling, repression of gene expression and control of cellular differentiation. ( NCI )] (UMLS (NCI) C1333894) HDAC5 Gene;
Histone Deacetylase 5 Gene =Gene or Genome ;
◊ [This protein belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. The gene is thought to be associated with colon cancer. Overexpression inhibits cell growth and induces apoptosis in tumor cell lines. (from LocusLink and Cancer Res 2002;62:2913-22) ( NCI )] (UMLS (NCI) C1334033) Histone Deacetylase 5 Amino Acid, Peptide, or Protein; Enzyme |
- 4. 5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-, Maleate(1:1)
- [The maleate salt form of trimipramine, a tricyclic secondary amine of the dibenzazepine class, with an antidepressant property. Trimipramine maleate appears to inhibit serotonin transport and norepinephrine uptake by nerve terminals. This increases available norepinephrine or serotonin and prolongs its action. ( NCI )] (UMLS (NCI) C0242523) =Organic Chemical; Pharmacologic Substance =TRIMIPRAMINE;
=TRIMIPRAMINE MALEATE 100 MG;
TRIMIPRAMINE MALEATE 25 MG;
TRIMIPRAMINE MALEATE 50 MG | - 18. HDAC6
- [HDAC6 functions as a tubulin deacetylase. HDAC6 is localized exclusively in the cytoplasm, where it associates with microtubules and localizes with the microtubule motor complex. In vivo the overexpression of HDAC6 led to a global deacetylation of alpha-tubulin, whereas a decrease in HDAC6 increased alpha-tubulin acetylation. In vitro, purified HDAC6 potently deacetylated alpha-tubulin in assembled microtubules. Furthermore, overexpression of HDAC6 promoted chemotactic cell movement, supporting the idea that HDAC6-mediated deacetylation regulates microtubule-dependent cell motility. Hubbert et al. (2002) concluded that HDAC6 is the tubulin deacetylase, and provided evidence that reversible acetylation regulates important biologic processes beyond histone metabolism and gene transcription. (from OMIM) ( NCI )] (UMLS (NCI) C0969119) Histone Deacetylase 6;
=Amino Acid, Peptide, or Protein; Enzyme ;
|
- 5. 5H-Dibenz(b,f)azepine-5-carboxamide
- [anticonvulsant and antineuralgic used in the treatment of pain associated with trigeminal neuralgia and in epilepsy manifested by tonic-clonic and partial seizures. ( CSP )] (UMLS (NCI) C0006949) =Organic Chemical; Pharmacologic Substance =[CN100] ANALGESICS;
[CN400] ANTICONVULSANTS;
azepine;
Dibenzazepines =10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide;
CARBAMAZEPINE 100 MG;
CARBAMAZEPINE 100 MG/5ML;
CARBAMAZEPINE 200 MG;
CARBAMAZEPINE 300 MG;
CARBAMAZEPINE 400 MG;
| - 19. HDAC6
- [This gene is involved in chromatin remodeling, repression of gene expression and cellular management of misfolded protein-induced stress. ( NCI )] (UMLS (NCI) C1333895) HDAC6 Gene;
Histone Deacetylase 6 Gene =Gene or Genome ;
|
- 6. 5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, Hydrochloride
- [The hydrochloride salt form of protriptyline, a tricyclic secondary amine with antidepressant property. Protriptyline hydrochloride blocks the re-uptake of norepinephrine and serotonin by nerve terminals, thereby increasing available norepinephrine and serotonin. Protriptyline does not block dopamine transport but may have an indirect dopamine-facilitating effect through interactions of increased peri-synaptic abundance of norepinephrine, particularly in the cerebral cortex, where adrenergic terminals exceed dopaminergic terminals. This results in elevation of mood and behavioral activity. In addition, this agent exhibits anticholinergic activity. ( NCI )] (UMLS (NCI) C0700557) =Organic Chemical; Pharmacologic Substance ;
=PROTRIPTYLINE;
=PROTRIPTYLINE HYDROCHLORIDE 10 MG;
PROTRIPTYLINE HYDROCHLORIDE 5 MG;
| - 20. HDGK DIS UNSP XTRNDL ORG
- (UMLS (ICD9CM) C0375086) =Neoplastic Process
|
- 7. H2D antigen
- [ ] (UMLS (CSP) C0599837) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 21. HDGK GRN UNSP XTRNDL ORG
- (UMLS (ICD9CM) C0375080) =Neoplastic Process
|
- 8. HD
- [chronic progressive chorea and mental deterioration terminating in dementia; the age of onset usually is in the fourth decade of life. ( CSP )] (UMLS (CSP) C0020179) =Disease or Syndrome =basal ganglia disease;
chorea;
Genetic Condition;
Arrieration mentale;
Organic Brain Syndrome;
Heredodegenerative Disorders, Nervous System | - 22. HDGK PRG UNSP XTRNDL ORG
- (UMLS (ICD9CM) C0686560) =Neoplastic Process
|
- 9. HDAC
- [Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases. There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM) ( NCI )] (UMLS (NCI) C0019643) =Amino Acid, Peptide, or Protein; Enzyme
| - 23. HDGK SRC UNSP XTRNDL ORG
- (UMLS (ICD9CM) C0375081) =Neoplastic Process
|
- 10. HDAC1
- [This gene plays a role in chromatin remodeling and the repression of gene expression. ( NCI )] (UMLS (NCI) C1333891) HDAC1 Gene;
Histone Deacetylase 1 Gene =Gene or Genome ;
◊ [Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. This protein belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (LocusLink) ( NCI )] (UMLS (NCI) C1334032) Histone Deacetylase 1 Amino Acid, Peptide, or Protein; Enzyme | - 24. HDL
- [class of lipoproteins that promote transport of cholesterol from extrahepatic tissue to the liver for excretion in the bile; synthesized by the liver as particles lacking a lipid core, they accumulate a core of cholesterol esters during reverse cholesterol transport and transfer them to the liver directly or indirectly via other lipoprotein; HDL also shuttle apolipoproteins C-II and E to and from triglyceride-rich lipoproteins during catabolism of the lipoproteins; serum HDL cholesterol has been negatively correlated with premature coronary heart disease. ( CSP )] (UMLS (NCI) C0023821) =Amino Acid, Peptide, or Protein; Lipid; Biologically Active Substance =blood lipoprotein;
|
- 11. HDAC2
- [One of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p, HDAC2 is found in transcription factor co-repressor complexes that include HDAC1. BRCA1 interacts with HDAC1 and HDAC2. Acetylation of histone destabilizes nucleosomes allowing transcription factors access to recognition elements in DNA. Deacetylation reseals the chromosomal package, repressing transcription. DNMT1 can establish a repressive transcription complex with HDAC2, and DMAP1. HDAC2 joins DNMT1 and DMAP1 during late S-phase, suggesting how histones may become deacetylated in heterochromatin following replication. (from OMIM 605164 and NCI) ( NCI )] (UMLS (NCI) C0768528) Histone Deacetylase 2;
Transcriptional Regulator Homolog RPD3 =Amino Acid, Peptide, or Protein; Enzyme ;
| - 25. HDL
- [A quantitative measurement of the amount of HDL cholesterol present in a sample of serum. ( NCI )] (UMLS (NCI) C0428472) =Laboratory Procedure
|
- 12. HDAC2
- [This gene is involved in chromatin remodeling, repression of gene expression and control of both cell proliferation and differentiation. ( NCI )] (UMLS (NCI) C1333892) HDAC2 Gene;
Histone Deacetylase 2 Gene =Gene or Genome ;
| - 26. HDL receptor
- [ ] (UMLS (CSP) C0062151) =Amino Acid, Peptide, or Protein; Receptor ;
|
- 13. HDAC3
- [Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. This protein belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. (LocusLink) ( NCI )] (UMLS (NCI) C1098658) Histone Deacetylase 3;
=Amino Acid, Peptide, or Protein; Enzyme ;
| - 27. HDNF
- [Expressed in brain and peripheral tissues, human NTF3 Gene (NGF-Beta Family) encodes secreted 257-aa 29-kDa (precursor) Neurotrophin 3, a neurotrophin closely related to NGF and BDNF that seems to control survival and differentiation of neurons and may be involved in maintenance of adult nervous system. The mature NTF3 peptide is identical in all mammals examined including human, pig, rat, and mouse. (NCI) ( NCI )] (UMLS (NCI) C0083735) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 14. HDAC3
- [This gene plays a role in chromatin remodeling, repression of gene expression and modulation of both cell growth and apoptosis. ( NCI )] (UMLS (NCI) C1366355) HDAC3 Gene;
Histone Deacetylase 3 Gene =Gene or Genome | |
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