Halobetasol

[A synthetic corticosteroid with anti-inflammatory, antipruritic and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activates gene expression of anti-inflammatory proteins mediated via corticosteroid receptor respond element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema and pruritus through its cutaneous effects on vascular dilation and permeability. ( NCI )]

UMLS (NCI) C0082787

Steroid
Pharmacologic Substance

Relation/PAR: 21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
[DE200] ANTI-INFLAMMATORY, TOPICAL

Relation/CHD: 21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate

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