Hematopoietic Protein Tyrosine Phosphatase
[Preferentially expressed as 2 distinct alternative isoforms in thymic and spleen hematopoietic cells by human early response PTPN7 Gene (Non-Receptor PTP Family) in lymphokine-stimulated cells, cytoplasmic Non-Receptor Type 7 Protein Tyrosine Phosphatase is likely involved in regulation of TCR signaling through dephosphorylating MAP kinase pathway molecules; the noncatalytic N-terminus interacts with and suppresses MAP kinase activities. PTPN7 appears to regulate T and B lymphocyte development and signal transduction. Protein Tyrosine Phosphatases typically regulate cellular processes including cell growth, differentiation, and mitotic cycle. (NCI) ( NCI )]
UMLS (NCI) C0379980- Amino Acid, Peptide, or Protein
- Enzyme
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