Heparanase
[With six potential N-glycosylation sites and hydrophobic stretches suggesting a transmembrane protein, ubiquitous 543-amino acid Heparanase, encoded by human HPSE Gene, is an endoglycosidase (beta-glucuronidase) that degrades heparan sulfate and related proteoglycans in the ECM and vascular basal laminar. Heparan sulfate degradation is key in tumor cell and migrating leukocyte extravasation. Heparanase activity is also important in angiogenesis, wound healing, and smooth muscle proliferation. (from LocusLink, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0062505- Amino Acid, Peptide, or Protein
- Enzyme
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