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SCL
[A probable positive hematopoietic transcriptional regulator, TAL1 belongs to the bHLH family and binds DNA as a hetero-dimer with E12 and E47, which recognize the enhancer E-box DNA motif (5'-CANNTG-3'). TAL1 also binds Rhombotin-2 and DRG1. Some T-ALL leukemias involve TAL1 and TCRA gene translocations, t(1;14)(p32;q11). (from SWISS-PROT P17542, OMIM 187040, and NCI) ( NCI )]
UMLS (NCI) C0378781- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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