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SDZ 280-446
[A novel semi-synthetic derivative of cyclosporin and a cyclodepsipeptide with chemo-sensitizing activity. SDZ 280-446 is one of the drug resistance-modifying agents that inhibit P-glycoprotein, the multidrug resistance efflux pump, thereby restoring the retention and activities of some drugs in drug-resistant tumor cells. ( NCI )]
UMLS (NCI) C0141820- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
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