CIS Family Protein
[Encoded by Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes, Suppressor of Cytokine Signaling Family Proteins are cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Containing SH2 and SOCS BOX domains, SOCS proteins are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI) ( NCI )]
UMLS (NCI) C1336534Cytokine-Induced STAT Inhibitor Family Protein
SOCS Family Protein
SSI Family Protein
STAT-Induced STAT Inhibitor Family Protein
Suppressor of Cytokine Signaling Family Protein
SOCS Family Protein
SSI Family Protein
STAT-Induced STAT Inhibitor Family Protein
Suppressor of Cytokine Signaling Family Protein
- Amino Acid, Peptide, or Protein
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