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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
C C- C1 C3 C5 C6 C7 CA CB CC CD CE CF CG CH CI CJ CK CL CM CN CO CP CQ CR CS CT CU CV CW CX CY CZ
CI CI CI- CI1 CI3 CI9 CIA CIB CIC CIF CIG CII CIL CIM CIN CIP CIR CIS CIT CIV

CIS

[Cytokine Inducible SH2-Containing Protein, encoded by the human CISH gene, is a cytokine-inducible negative regulator of cytokine signaling. This protein contains a SH2 domain and a SOCS box domain. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein is involved in the inactivation of the erythropoietin receptor. Association with EPOR may target this protein for proteolysis by the ubiquitin-dependent proteasome pathway. The CISH protein is mainly monoubiquitinated (37 kD) but may also exist in a polyubiquitinated form (45 kD). Three isoforms (1, 1B, 1C) are produced by alternative splicing, and the tissue distribution of isoforms 1 and 1B is distinct. (From LocusLink, Swiss-Prot and NCI) ( NCI )]
UMLS (NCI) C0299250
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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