CO COA COB COC COD COE COF COG COH COI COK COL COM CON COO COP COQ COR COS COT COU COV COW COX COY COZ
Cofactor Required for Sp1 Transcriptional Activation Subunit 2
[Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP2 gene at Xp11.4-p11.2 encodes a 150-kD protein that is subunit 2 of the CRSP complex. This CRSP2 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. CRSP2 contains a cytochrome C family heme-binding motif and a bipartite nuclear localization signal. (from OMIM 300182, LocusLink 9282) ( NCI )]
UMLS (NCI) C1313003CRSP2
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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