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Cofactor Required for Sp1 Transcriptional Activation Subunit 3
[Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation) along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP3 gene encodes this 130-kD protein that is subunit 3 of the CRSP complex. The CRSP3 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. (from OMIM 605042, LocusLink 9439) ( NCI )]
UMLS (NCI) C1313004CRSP3
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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