[Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. ( NCI )]
UMLS (NCI) C1313007CRSP6
- Amino Acid, Peptide, or Protein
- Biologically Active Substance