[Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP8 gene encodes this 34-kD protein that is subunit 8 of the CRSP complex. The CRSP8 protein is required for Sp1-mediated transcriptional activation with TAF(II)s. (from OMIM 605044, LocusLink 9442) ( NCI )]
UMLS (NCI) C1313009CRSP8
- Amino Acid, Peptide, or Protein
- Biologically Active Substance