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Cofactor Required for Sp1 Transcriptional Activation Subunit 9
[Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP9 gene encodes this 33-kD protein that is subunit 9of the CRSP complex. The CRSP9 protein is required with the TAF(II)s for Sp1-mediated transcriptional activation. (from OMIM 605045, LocusLink 9443) ( NCI )]
UMLS (NCI) C1313010CRSP9
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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